CCL-CM124-100μg / 询价
CCL-CM124-500μg / 询价
CCL-CM124-500μgx2 / 询价
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Cynomolgus CCL24 Protein
Recombinant Cynomolgus CCL24 Protein is expressed from HEK293 with His tag at the N-Terminus.It contains His19-His119 [Accession | XP_005549400.1].
The protein has a predicted MW of 12.36 kDa. Due to glycosylation, the protein migrates to 23-38 kDa based on Bis-Tris PAGE result.
> 90% as determined by Bis-Tris PAGE
> 90% as determined by HPLC
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Cynomolgus CCL24 on Bis-Tris PAGE under reduced condition. The purity is greater than 90%.
The purity of Cynomolgus CCL24 is greater than 90% as determined by SEC-HPLC.
Immobilized Cynomolgus CCL24, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Anti-CCL24 Antibody, hFc Tag with the EC50 of 18.7ng/ml determined by ELISA.
C-C motif chemokine ligand 24 (CCL24) is a chemokine that regulates inflammatory and fibrotic activities through its receptor, C-C motif chemokine receptor (CCR3). CCL24 is a chemokine that regulates inflammation and fibrosis. It was found to be significantly expressed in patients with non-alcoholic steatohepatitis, in whom it regulates profibrotic processes in the liver.
CK-beta-6; Eotaxin-2; MPIF-2; MPIF2; SCYA24; Ckb-6; CCL24; member 24;CK-β-6
(1) Segal-Salto M, Barashi N, Katav A, Edelshtein V, Aharon A, Hashmueli S, George J, Maor Y, Pinzani M, Haberman D, Hall A, Friedman S, Mor A. A blocking monoclonal antibody to CCL24 alleviates liver fibrosis and inflammation in experimental models of liver damage. JHEP Rep. 2020 Jan 2;2(1):100064. doi: 10.1016/j.jhepr.2019.100064. PMID: 32039405; PMCID: PMC7005554.
