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FGFR系列蛋白
FGFR（Fibroblast Growth Factor Receptors），即成纤维细胞生长因子受体，一般包括FGFR1-4（也称CD331-334）四种类型。FGFR是酪氨酸酶受体家族的一支，为I型跨膜蛋白，包括胞外区、跨膜区和胞质区，通常以二聚体形式发挥作用。其中，胞外结构域包含三个Ig样区域D1（IgI）、D2（IgII）、D3（IgIII），其中D1和Acidic box组成自抑制区；D2和D3负责与配体结合（D2与细胞表面硫酸乙酰肝素结合，D3由于可变剪接有IIIb和IIIc两种形式，FGFR4中目前只发现IIIc一种亚型）。根据Ig样结构域的个数，FGFR可分为两种形式，一种是α型，含有IgI, IgII, IgIII三个区域；另一种是β型，只含IgII和IgIII。
FGFR结构（Babina IS, et al., 2017）
FGFR的配体为FGF，目前已发现的人FGF有18种，除了FGF19、FGF21、FGF23是内分泌外，其余皆为旁分泌产生，其中FGF7只能与IIIb型的FGFR2结合。FGFR与FGF结合介导了RAS-RAF-MAPK、PI3K-AKT、JAK-STAT以及PLCγ等信号通路的激活传递，参与细胞生长、分化、迁移、新血管生成、调节器官发育和伤口愈合等重要生理过程。FGFR基因变异通常在肺癌、肝癌、肝内胆管癌、乳腺癌、胃癌、子宫癌及膀胱癌等实体瘤中广泛存在，并且不同癌种的FGFR突变类型及频率也存在差异。
FGF-FGFR介导的信号通路（Mason I, 2007）
恺佧生物深入分析了FGFR家族蛋白的结构差异，成功制备出多种类型FGFR重组蛋白，涵盖了α和β亚型，以及IIIb和IIIc等不同形式，助力FGFR靶向药物的差异化研究！
质控示例
Human FGFR2 beta (IIIb) Protein（FGR-HM1BB）
Immobilized Human FGFR2 beta(IIIb) at 0.5μg/ml on the plate. Dose response curve for Anti-FGFR2 Ab., hFc Tag with the EC50 of 20.2ng/ml determined by ELISA.
Anti-FGFR2 Ab., hFc Tag can bind Human FGFR2 beta IIIb, His Tag with an affinity constant of 1.98nM as determined in a SPR assay (Biacore T200).
Human FGFR2 alpha (IIIb) Protein（FGR-HM1BD）
Serial dilutions of Anti-FGFR2 alpha (IIIb) Antibody were added into Human FGFR2 alpha (IIIb), His Tag : Biotinylated Human FGF10, No Tag binding reactioins.
产品列表
| 货号 | 蛋白名称 | 种属 | 标签 | 表达体系 | |
|---|---|---|---|---|---|
| FGF-HM4RA | Human FGFR1 alpha (IIIc) Protein | Human | C-His-Avi | HEK293 | 立即询价 |
| FGF-HM4RAB | Biotinylated Human FGFR1 alpha (IIIc) Protein | Human | C-His-Avi | HEK293 | 立即询价 |
| FGF-HM2RA | Human FGFR2 alpha (IIIb) Protein | Human | C-hFc | HEK293 | 立即询价 |
| FGR-HM1BD | Human FGFR2 alpha (IIIb) Protein | Human | C-His | HEK293 | 立即询价 |
| FGF-HM4ABB | Biotinylated Human FGFR2 alpha (IIIb) Protein | Human | C-His-Avi | HEK293 | 立即询价 |
| FGR-HM2CD | Human FGFR2 alpha (IIIc) Protein | Human | C-His | HEK293 | 立即询价 |
| FGR-HM4CDB | Biotinylated Human FGFR2 alpha (IIIc) Protein | Human | C-His-Avi | HEK293 | 立即询价 |
| FGR-HM1BB | Human FGFR2 beta (IIIb) Protein | Human | C-His | HEK293 | 立即询价 |
| FGR-HM4BBB | Biotinylated Human FGFR2 beta (IIIb) Protein | Human | C-His-Avi | HEK293 | 立即询价 |
| FGF-HM12D | Human FGFR2 beta (IIIb) Protein | Human | C-His | HEK293 | 立即询价 |
| FGF-CM1BB | Cynomolgus FGFR2 beta (IIIb) Protein | Cynomolgus | C-His | HEK293 | 立即询价 |
| FGF-MM1BB | Mouse FGFR2 beta (IIIb) Protein | Mouse | C-His | HEK293 | 立即询价 |
| FGR-HM1BC | Human FGFR2 beta (IIIc) Protein | Human | C-His | HEK293 | 立即询价 |
| FGR-HM4BCB | Biotinylated Human FGFR2 beta (IIIc) Protein | Human | C-His-Avi | HEK293 | 立即询价 |
| FGF-HM43B | Human FGFR3 alpha (IIIb) Protein | Human | C-His-Avi | HEK293 | 立即询价 |
| FGF-HM43BB | Biotinylated Human FGFR3 alpha (IIIb) Protein | Human | C-His-Avi | HEK293 | 立即询价 |
| FGF-HM43C | Human FGFR3 alpha (IIIc) Protein | Human | C-His-Avi | HEK293 | 立即询价 |
| FGF-HM43CB | Biotinylated Human FGFR3 alpha (IIIc) Protein | Human | C-His-Avi | HEK293 | 立即询价 |
| FGF-HM4BB | Human FGFR3 beta (IIIb) Protein | Human | C-His-Avi | HEK293 | 立即询价 |
| FGF-HM4BBB | Biotinylated Human FGFR3 beta (IIIb) Protein | Human | C-His-Avi | HEK293 | 立即询价 |
| FGF-HM4BC | Human FGFR3 beta (IIIc) Protein | Human | C-His-Avi | HEK293 | 立即询价 |
| FGF-HM4BCB | Biotinylated Human FGFR3 beta (IIIc) Protein | Human | C-His-Avi | HEK293 | 立即询价 |
| FGF-HM4R4 | Human FGFR4 Protein | Human | C-His-Avi | HEK293 | 立即询价 |
| FGF-HM2BD | Human FGFR2 beta (IIIb) Domain Protein | Human | C-hFc | HEK293 | 立即询价 |
| FGR-HM2BB | Human FGFR2 beta (IIIb) Protein | Human | C-hFc | HEK293 | 立即询价 |
| FGF-HM2R4 | Human FGFR4 Protein | Human | C-hFc | HEK293 | 立即询价 |
| FGF-HM4R4B | Biotinylated Human FGFR4 Protein | Human | C-His-Avi | HEK293 | 立即询价 |
| FGF-HE001 | Human FGF basic | Human | No Tag | E.coli | 立即询价 |
| KGF-HE101 | Human FGF-7/KGF | Human | N-His | E.coli | 立即询价 |
| FGF-HE010 | Human FGF10 | Human | No Tag | E.coli | 立即询价 |
| FGF-HM621 | Human FGF21 | Human | N-mFc-Avi | HEK293 | 立即询价 |
| FGF-HM121 | Human FGF21 | Human | N-His | HEK293 | 立即询价 |
| FGF-HM621B | Biotinylated Human FGF21 | Human | N-mFc-Avi | HEK293 | 立即询价 |
| FGF-MM121 | Mouse FGF21 | Mouse | N-His | HEK293 | 立即询价 |
| KLB-HM101 | Human Beta-Klotho Protein | Human | C-His | HEK293 | 立即询价 |
