CD8-HM18H-100μg / 询价
CD8-HM18H-500μg / 询价
CD8-HM18H-500μgx2 / 询价
Human CD28H/IGPR-1 Protein
Recombinant Human CD28H/IGPR-1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Leu23-Gly150 [Accession | Q96BF3-1].
The protein has a predicted MW of 15.1 kDa. Due to glycosylation, the protein migrates to 42-52 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1EU per ug by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human CD28H on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human CD28H is greater than 95% as determined by SEC-HPLC.
Immobilized Human CD28H, His Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Human B7-H7, hFc Tag with the EC50 of 90.0ng/ml determined by ELISA.
CD28H is constitutively expressed on all naive T cells. Repetitive antigenic exposure, however, induces a complete loss of CD28H on many T cells, and CD28H negative T cells have a phenotype of terminal differentiation and senescence. After extensive screening in a receptor array, a B7-like molecule, B7 homologue 5 (B7-H5), was identified as a specific ligand for CD28H.
TMIGD2; IGPR1; IGPR-1; CD28H; TPC1
(1) Zhu Y, Yao S, Iliopoulou BP, Han X, Augustine MM, Xu H, Phennicie RT, Flies SJ, Broadwater M, Ruff W, Taube JM, Zheng L, Luo L, Zhu G, Chen J, Chen L. B7-H5 costimulates human T cells via CD28H. Nat Commun. 2013;4:2043. doi: 10.1038/ncomms3043. PMID: 23784006; PMCID: PMC3698612.
