Biotinylated Human Claudin 6 Protein-VLP
Recombinant Biotinylated Full length Human Claudin 6 Protein-VLP is expressed from HEK293. It contains Met1-Val220.[Accession | P56747]
The target protein has a predicted MW of 24.5 kDa.
Less than 1EU per μl by the LAL method.
> 95% as determined by HPLC
Supplied as 0.22μm filtered solution in PBS, 300mM L-arginine (pH 7.4).
Valid for 6 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
The purity of Biotinylated Human Claudin 6 VLP is greater than 95% as determined by SEC-HPLC.
Biotinylated Human Claudin 6 VLP captured on CM5 Chip via Streptavidin can bind Anti-Claudin6 Antibody with an affinity constant of 0.65 nM as determined in SPR assay (Biacore T200).
Claudin-6 is a multipass transmembrane protein in the Claudin family. Claudin-6 is expressed by epithelial cells where it participates in tissue development and the maintenance of tight junction integrity. Human Claudin-6 shares 88% and 86% amino acid sequence identity with mouse and rat Claudin-6, respectively.
Claudin-6; Skullin; CLDN6; Claudin6; Skullin 2
(1) Sugimoto K, Ichikawa-Tomikawa N, Kashiwagi K, Endo C, Tanaka S, Sawada N, Watabe T, Higashi T, Chiba H. Cell adhesion signals regulate the nuclear receptor activity. Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24600-24609. doi: 10.1073/pnas.1913346116. Epub 2019 Nov 18. PMID: 31740618; PMCID: PMC6900646.
