CLD-HM009-100μg / 询价
CLD-HM009-100μg x 5 / 询价
CLD-HM009-100μg x 10 / 询价
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Human Claudin 9 Protein-VLP
Recombinant Human Claudin 9 Protein-VLP is expressed from HEK293.It contains Met1-Val217 [Accession | O95484].
The target protein has a predicted MW of 24.1 kDa.
> 95% as determined by HPLC
Less than 1EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS, 300mM L-Arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
The purity of Human Claudin 9 VLP is greater than 95% as determined by SEC-HPLC.
Immobilized Human Claudin 9 VLP at 2μg/ml (100μl/well) on the plate. Dose response curve for Anti-Claudin 9 Antibody, hFc Tag with the EC50 of 1.8ng/ml determined by ELISA.
Claudins (CLDNs) are tetraspan proteins with a short cytoplasmic N‑terminus, two extracellular loops and a C‑terminal cytoplasmic domain. They function as a physical barrier or gate of small molecules and as signaling platforms to coordinate diverse cellular behaviors. CLDNs are useful cancer biomarkers, as they are frequently upregulated and are associated with malignant traits of cancers, such as invasion, migration, metastasis and chemoresistance. Claudin‑9 (CLDN9) is barely distributed in normal adult tissues but is ectopically expressed in various cancer types.
CLDN9; Claudin-9; Claudin9;
Endo Y, Sugimoto K, Kobayashi M, Kobayashi Y, Kojima M, Furukawa S, Soeda S, Watanabe T, Higashi AY, Higashi T, Hashimoto Y, Fujimori K, Chiba H. Claudin‑9 is a novel prognostic biomarker for endometrial cancer. Int J Oncol. 2022 Nov;61(5):135. doi: 10.3892/ijo.2022.5425. Epub 2022 Sep 21. PMID: 36129146; PMCID: PMC9521636.
