Biotinylated Human Claudin 18.2 Protein-VLP
Recombinant Biotinylated Human Claudin 18.2 Protein-VLP is expressed from HEK293.It contains Met1-Val261 [Accession | P56856-2].
The target protein has a predicted MW of 29 kDa.
Less than 1EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS, 150mM L-Arginine (pH 7.4).
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Biotinylated Human Claudin18.2 VLP (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Anti-Claudin 18.2 Antibody, hFc Tag with the EC50 of 15.9ng/ml determined by ELISA.
Claudin18 (CLDN18) belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 is specifically expressed in the stomach and lung. CLDN18 has two alternatively spliced variants, CLDN18.1 and CLDN18.2. Isoform 2 (Claudin 18.2) is abundant in gastric tumors.
CLDN18; CLDN18.2; Claudin-18.2; Claudin18.2
(1) Singh P , Toom S , Huang Y. Anti-claudin 18.2 antibody as new targeted therapy for advanced gastric cancer[J]. Journal of Hematology & Oncology, 2017, 10(1):105.
