FITC-equivalent Biotinylated Human Claudin 18.2 Protein-VLP
Recombinant Biotinylated Human Claudin 18.2 Protein-VLP V2 is expressed from HEK293.It contains Met1-Val261 [Accession | P56856-2].
The target protein has a predicted MW of 29 kDa.
Excitation Wavelength: 490 nm
Emission Wavelength: 520 nm
Less than 1EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS, 150mM L-Arginine (pH 7.4).
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
FITC-equivalent Biotinylated Human Claudin 18.2 VLP captured on CM5 Chip via Steptavidin can bind Anti-Claudin18.2 Antibody with an affinity constant of 16.38 pM as determined in SPR assay (Biacore T200) (QC Test).
Loaded FITC-equivalent Biotinylated Human Claudin 18.2 VLP on SA-Biosensor, can bind Anti-Claudin18.2 Antibody with an affinity constant of 0.15 nM as determined in BLI assay (Gator Prime).
Claudin18 (CLDN18) belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 is specifically expressed in the stomach and lung. CLDN18 has two alternatively spliced variants, CLDN18.1 and CLDN18.2. Isoform 2 (Claudin 18.2) is abundant in gastric tumors.
CLDN18; CLDN18.2; Claudin-18.2; Claudin18.2
(1) Singh P , Toom S , Huang Y. Anti-claudin 18.2 antibody as new targeted therapy for advanced gastric cancer[J]. Journal of Hematology & Oncology, 2017, 10(1):105.
