CLD1-HM1N184-100μg / 询价
CLD1-HM1N184-100μg x 5 / 询价
CLD1-HM1N184-100μg x 10 / 询价
- 客服电话
- 技术支持
FITC-equivalent Human Claudin 1 Protein-Nanodisc
Recombinant FITC-equivalent Human Claudin 1 Protein-Nanodisc is expressed from HEK293 with His tag at the N-terminus.It contains Met1-Val211 [Accession | O95832].
The protein has a predicted MW of 48.5 kDa.
Excitation Wavelength: 490 nm
Emission Wavelength: 520 nm
Less than 1EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS (pH 7.4). Notice: Not recommended for immunization.
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized FITC-equivalent Human Claudin 1 Nanodisc, His Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Anti-Claudin 1 Antibody, hFc Tag with the EC50 of 0.32μg/ml determined by ELISA (QC Test).
Claudin-1 (CLDN1), a major component of tight junction complexes in the epithelium, maintains cellular polarity, and plays a critical role in cell-to-cell communication as well as epithelial cell homeostasis. Moreover, CLDN1 expression is up-regulated in several cancers, and the level of CLDN1 expression has been proposed as a prognostic marker of patient survival.
Claudin-1; CLDN1; CLD1; SEMP1
(1) Clément CMH, Deffieu MS, Dorobantu CM, Baumert TF, Ayala-Nunez NV, Mély Y, Ronde P, Gaudin R. Characterisation of endogenous Claudin-1 expression, motility and susceptibility to hepatitis C virus in CRISPR knock-in cells. Biol Cell. 2020 May;112(5):140-151. doi: 10.1111/boc.201900085. Epub 2020 Feb 20. PMID: 32034780; PMCID: PMC7613415.
(2) Chang JW, Seo ST, Im MA, Won HR, Liu L, Oh C, Jin YL, Piao Y, Kim HJ, Kim JT, Jung SN, Koo BS. Claudin-1 mediates progression by regulating EMT through AMPK/TGF-β signaling in head and neck squamous cell carcinoma. Transl Res. 2022 Sep;247:58-78. doi: 10.1016/j.trsl.2022.04.003. Epub 2022 Apr 22. PMID: 35462077.
