DLL-CM103-100μg / 询价
DLL-CM103-500μg / 询价
DLL-CM103-500μgx2 / 询价
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Cynomolgus DLL3 Protein
Recombinant Cynomolgus DLL3 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ala27-Ala477 [Accession | A0A2K5WSR1].
The protein has a predicted MW of 48.80 kDa. Due to glycosylation, the protein migrates to 52-62 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22 μm filtered solution in 20mM Tris, 200mM NaCl, 200mM L-arginine (pH 8.5). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Cynomolgus DLL3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Immobilized Cynomolgus DLL3, His Tag at 0.2μg/ml (100μl/well) on the plate. Dose response curve for Anti-DLL3 Antibody, hFc Tag with the EC50 of 5.0ng/ml determined by ELISA.
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).
Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3
(1)Saunders L R , Bankovich A J , Anderson W C , et al. A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo[J]. Science Translational Medicine, 2015.
