LR5-HM1N157-100μg / 询价
LR5-HM1N157-100μg x 5 / 询价
LR5-HM1N157-100μg x 10 / 询价
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Human LGR-5 Protein-Nanodisc
Recombinant Human LGR-5 Protein-Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Gly22-Pro543 [Accession | O75473-1].
The protein has a predicted MW of 101.35 kDa.
Less than 1EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS (pH 7.4). Notice: Not recommended for immunization.
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Human R-Spondin 3, hFc Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Human LGR-5 Nanodisc, His Tag with the EC50 of 0.68μg/ml determined by ELISA.
G protein-coupled receptor 5 (LGR5), known as a stem cell marker for colon cancer and gastric cancer, can serve as a novel GSC marker involved in EMT and a therapeutic target in glioma.LGR5 is a new functional GSC marker and prognostic indicator that can promote EMT by activating the Wnt/β-catenin pathway and would thus be a novel therapeutic target for glioma.
LGR5; GPR49; GPR67; HG38; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38
Zhang J, Cai H, Sun L, Zhan P, Chen M, Zhang F, Ran Y, Wan J. LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/β-catenin pathway and predicts poor survival of glioma patients. J Exp Clin Cancer Res. 2018 Sep 12;37(1):225. doi: 10.1186/s13046-018-0864-6. PMID: 30208924; PMCID: PMC6136228.
