ASG-HM1R1 | 价格

ASG-HM1R1-100μg / 询价

ASG-HM1R1-500μg / 询价

ASG-HM1R1-500μgx2 / 询价

Human ASGR1 Protein

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant Human ASGR1 Protein is expressed from HEK293 with His tag at the N-Terminus.
It contains Gln62-Leu291 [Accession | P07306-1].

分子量大小(Molecular Weight)

The protein has a predicted MW of 27.49 kDa. Due to glycosylation, the protein migrates to 38-55 kDa based on Bis-Tris PAGE result.

纯度(Purity)

> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC

内毒素(Endotoxin)

Less than 1EU per μg by the LAL method.

制剂(Formulation)

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

重构方法(Reconstitution)

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

存储(Storage)

-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

产品数据(Assay Data)
Bis-Tris PAGE

Human ASGR1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC

The purity of Human ASGR1 is greater than 95% as determined by SEC-HPLC.

背景(Background)

ASGR1 is a liver-specific surface marker that is exclusively expressed in liver and mediates internalization and lysosomal degradation of blood asialoglycoproteins.

分子别名(Synonyms)

ASGP-R 1; ASGPR 1; Hepatic lectin 1; HL-1; mHL-1; Asgr1; Asgr-1;

文献(References)

Wang JQ, Li LL, Hu A, Deng G, Wei J, Li YF, Liu YB, Lu XY, Qiu ZP, Shi XJ, Zhao X, Luo J, Song BL. Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion. Nature. 2022 Aug;608(7922):413-420. doi: 10.1038/s41586-022-05006-3. Epub 2022 Aug 3. PMID: 35922515.

Note: HPLC results always come from liquid protein, due to absorption peak interference of trehalose in lyophilized powder.