GHR-HM101-100μg / 询价
GHR-HM101-500μg / 询价
GHR-HM101-500μgx2 / 询价
表达区间及表达系统(Source)
|
Recombinant Human GHR/Growth Hormone R Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ala27-Tyr264 [Accession | P10912-1]. |
分子量大小(Molecular Weight)
|
The protein has a predicted MW of 28.8 kDa. Due to glycosylation, the protein migrates to 45-60 kDa based on Bis-Tris PAGE result. |
纯度(Purity)
|
> 95% as determined by Bis-Tris PAGE |
内毒素(Endotoxin)
|
Less than 1EU per μg by the LAL method. |
制剂(Formulation)
|
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
重构方法(Reconstitution)
|
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
存储(Storage)
|
-20 to -80°C for 12 months as supplied from date of receipt. |
Recombinant Human GHR/Growth Hormone R Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ala27-Tyr264 [Accession | P10912-1].
The protein has a predicted MW of 28.8 kDa. Due to glycosylation, the protein migrates to 45-60 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Pegvisomant, a growth hormone receptor (GHR) antagonist, is a well-known drug that was designed to treat acromegaly. However, recent studies have indicated that the GHR is a "moonlighting" protein that may exhibit dual functions based on its localization in the plasma membrane and nucleus.
GH receptor; GHBP; GHR; GHR/BP
(1) Lan H, Li W, Li R, Zheng X, Luo G. Endocytosis and Degradation of Pegvisomant and a Potential New Mechanism That Inhibits the Nuclear Translocation of GHR. J Clin Endocrinol Metab. 2019 Jun 1;104(6):1887-1899. doi: 10.1210/jc.2018-02063. PMID: 30602026.
GHR-HM101-100μg / 询价
GHR-HM101-500μg / 询价
GHR-HM101-500μgx2 / 询价
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