货号价格

IL1-HM2RC-100μg / 询价

IL1-HM2RC-500μg / 询价

IL1-HM2RC-500μgx2 / 询价

Human IL-17Rc Protein

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant Human IL-17Rc Protein is expressed from HEK293 with hFc tag at the C-Terminus.
It contains Leu21-Arg467 [Accession | NP_703190.2].

分子量大小(Molecular Weight)

The protein has a predicted MW of 76.2 kDa. Due to glycosylation, the protein migrates to 90-115 kDa based on Bis-Tris PAGE result.

纯度(Purity)

> 95% as determined by Bis-Tris PAGE

内毒素(Endotoxin)

Less than 1EU per μg by the LAL method.

制剂(Formulation)

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

重构方法(Reconstitution)

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

存储(Storage)

-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

产品数据(Assay Data)
Bis-Tris PAGE

Human IL-17Rc on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

ELISA Data

Immobilized Human IL-17A, His Tag at 2μg/ml (100μl/Well) on the plate. Dose response curve for Human IL-17Rc, hFc Tag with the EC50 of 33.8ng/ml determined by ELISA (QC Test).

背景(Background)

IL-17RC (interleukin-17 receptor-like) gene codes for a transmembrane protein, the full length of which inhibits apoptosis in prostate cancer cells. IL-17RC gene transcribes over a dozen different splice variants of mRNA. IL-17RC protein isoforms are differentially expressed in prostatic cells and cancer tissues and may play a negative or positive role in the initiation and progression of prostate cancer.

分子别名(Synonyms)

IL-17 receptor C; IL-17RC; IL17Rhom; IL-17RL; ZcytoR14

文献(References)

(1) You Z, Dong Y, Kong X, Zhang Y, Vessella RL, Melamed J. Differential expression of IL-17RC isoforms in androgen-dependent and androgen-independent prostate cancers. Neoplasia. 2007 Jun;9(6):464-70. doi: 10.1593/neo.07109. PMID: 17603628; PMCID: PMC1899256.