ILR-HM2R3-100μg / 询价
ILR-HM2R3-500μg / 询价
ILR-HM2R3-500μgx2 / 询价
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Human IL-1R3/IL-1 RAcP Protein
Recombinant Human IL-1R3/IL-1 RAcP Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Ser21-Glu359 [Accession | Q9NPH3-1].
The protein has a predicted MW of 65.8 kDa. Due to glycosylation, the protein migrates to 75-85 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 24 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
2-8°C for 2-7 days after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human IL-1R3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human IL-1R3 is greater than 95% as determined by SEC-HPLC.
Immobilized Human IL-1R3, hFc Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Anti-IL-1R3 Antibody, hFc Tag with the EC50 of 18.6ng/ml determined by ELISA.
IL-1 Receptor Accessory Protein (IL-1 RAcP), also known as IL-1 R3, is a ubiquitously expressed 70-90 kDa member of the Interleukin-1 receptor family of proteins. It serves as a non-ligand-binding component of the receptors for IL-1 alpha, IL-1 beta, IL-33, and IL-36. IL-1 R3 is a coreceptor for IL1RL2 in the IL-36 signaling system. IL-1 R3 is a coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways.
IL1RAP; IL-1RAP; C3orf13; IL-1 R3; IL-1 RAcP
(1)gerstam, Helena, Karlsson C , Hansen N , et al. Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia[J]. Proceedings of the National Academy of Sciences, 2015, 112(34):10786-10791.
