MHC-HM430-100μg / 询价
MHC-HM430-500μg / 询价
MHC-HM430-500μgx2 / 询价
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Human HLA-A*24:02&B2M&Survivin 2B (AYACNTSTL) Monomer Protein
Recombinant Human Survivin 2B(HLA-A*24:02) Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Gly25-Thr305(HLA-A*24:02), Ile21-Met119(B2M) and AYACNTSTL peptide [Accession | AAA59600.1(HLA-A*24:02)&P61769(B2M)&AYACNTSTL].
The protein has a predicted MW of 50.20 kDa. Due to glycosylation, the protein migrates to 53-63 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human HLA-A*24:02&B2M&Survivin 2B (AYACNTSTL) Monomer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human HLA-A*24:02&B2M&Survivin 2B (AYACNTSTL) Monomer is greater than 95% as determined by SEC-HPLC.
Survivin-2B, a known splice variant of survivin, has been reported to promote cell death in some cancer cells, although it keeps prosurvival function in others.survivin-2B promoted autophagy and further regulated cell death by accumulating and stabilizing IKK alpha in the nucleus.
svn-2B; Survivin-2B; svn 2B
Shi K, An J, Shan L, Jiang Q, Li F, Ci Y, Wu P, Duan J, Hui K, Yang Y, Xu C. Survivin-2B promotes autophagy by accumulating IKK alpha in the nucleus of selenite-treated NB4 cells. Cell Death Dis. 2014 Feb 20;5(2):e1071. doi: 10.1038/cddis.2014.34. PMID: 24556686; PMCID: PMC3944251.
