PGL-MM201 | 价格

PGL-MM201-100μg / 询价

PGL-MM201-500μg / 询价

PGL-MM201-500μgx2 / 询价

Mouse PGLYRP1 Protein

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant Mouse PGLYRP1 Protein is expressed from HEK293 with hFc tag at the C-Terminus.
It contains Phe19-Glu182 [Accession | O88593].

分子量大小(Molecular Weight)

The protein has a predicted MW of 45.7 kDa. Due to glycosylation, the protein migrates to 50-55 kDa based on Bis-Tris PAGE result.

纯度(Purity)

> 95% as determined by Bis-Tris PAGE

内毒素(Endotoxin)

Less than 1EU per μg by the LAL method.

制剂(Formulation)

Supplied as 0.22μm filtered solution in PBS, 10% Glycerol (pH 8.0).

存储(Storage)

Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

产品数据(Assay Data)
Bis-Tris PAGE

Mouse PGLYRP1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC

The purity of Mouse PGLYRP1 is greater than 95% as determined by SEC-HPLC.

背景(Background)

Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major heat shock protein Hsp70 can activate TNFR1 receptor and induce tumor cell death via either apoptotic or necroptotic pathway.

分子别名(Synonyms)

PGRP-S; PGLYRP1; PGLYRP; PGRP; TNFSF3L; PGRP-SMGC126894; PGRPSMGC126896; TAG7; Tasg7

文献(References)

(1) Romanova EA, Sharapova TN, Telegin GB, Minakov AN, Chernov AS, Ivanova OK, Bychkov ML, Sashchenko LP, Yashin DV. A 12-mer Peptide of Tag7 (PGLYRP1) Forms a Cytotoxic Complex with Hsp70 and Inhibits TNF-Alpha Induced Cell Death. Cells. 2020 Feb 20;9(2):488. doi: 10.3390/cells9020488. PMID: 32093269; PMCID: PMC7072780.