PVR-MM501 | 价格

PVR-MM501-100μg / 询价

PVR-MM501-500μg / 询价

PVR-MM501-500μgx2 / 询价

Mouse PVRIG Protein

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant Mouse PVRIG Protein is expressed from HEK293 with hFc tag and Avi tag at the C-Terminus.
It contains Ser35-Asp165 [Accession | A0A1B0GS01].

分子量大小(Molecular Weight)

The protein has a predicted MW of 42.70 kDa. Due to glycosylation, the protein migrates to 53-63 kDa based on Bis-Tris PAGE result.

纯度(Purity)

> 95% as determined by Bis-Tris PAGE

内毒素(Endotoxin)

Less than 1EU per μg by the LAL method.

制剂(Formulation)

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

重构方法(Reconstitution)

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

存储(Storage)

-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

产品数据(Assay Data)
Bis-Tris PAGE

Mouse PVRIG on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

ELISA Data

Immobilized Mouse Nectin-2, His Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Mouse PVRIG, hFc Tag with the EC50 of 0.62μg/ml determined by ELISA (QC Test).

背景(Background)

Murine PVRIG interacted weakly with poliovirus receptor (PVR) but bound poliovirus receptor-like 2 (PVRL2) strongly, making the latter its principal ligand.PVRIG is an inducible checkpoint receptor and that targeting PVRIG-PVRL2 interactions results in increased CD8+ T-cell function and reduced tumor growth.

分子别名(Synonyms)

C7orf15; CD112R; MGC104322; MGC138297; MGC2463; PVRIG; ALS2CR18; ALS2CR9; LPD; PREL-2; PREL2; RalGDS/AF-6; RMO1

文献(References)

Murter B, Pan X, Ophir E, Alteber Z, Azulay M, Sen R, Levy O, Dassa L, Vaknin I, Fridman-Kfir T, Salomon R, Ravet A, Tam A, Levin D, Vaknin Y, Tatirovsky E, Machlenkin A, Pardoll D, Ganguly S. Mouse PVRIG Has CD8+ T Cell-Specific Coinhibitory Functions and Dampens Antitumor Immunity. Cancer Immunol Res. 2019 Feb;7(2):244-256. doi: 10.1158/2326-6066.CIR-18-0460. Epub 2019 Jan 18. PMID: 30659055; PMCID: PMC7038785.