SEZ-HM1L2 | 价格

SEZ-HM1L2-100μg / 询价

SEZ-HM1L2-500μg / 询价

SEZ-HM1L2-500μgx2 / 询价

Human SEZ6L2 Protein

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant Human SEZ6L2 Protein is expressed from HEK293 with His tag at the C-Terminus.
It contains Leu28-Asn844 [Accession | Q6UXD5-1].

分子量大小(Molecular Weight)

The protein has a predicted MW of 88.5 kDa. Due to glycosylation, the protein migrates to 120-140 kDa based on Bis-Tris PAGE result.

纯度(Purity)

> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC

内毒素(Endotoxin)

Less than 1EU per μg by the LAL method.

制剂(Formulation)

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

重构方法(Reconstitution)

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

存储(Storage)

-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

产品数据(Assay Data)
Bis-Tris PAGE

Human SEZ6L2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC

The purity of Human SEZ6L2 is greater than 95% as determined by SEC-HPLC.

背景(Background)

Seizure-related 6 homolog (mouse)-like 2 (SEZ6L2) was shown to be involved in transcription of a type 1 transmembrane protein for regulating cell fate. SEZ6L2 was significantly up-regulated in tumour tissues of patients with CRC compared with adjacent normal tissues. Up-regulation of SEZ6L2 was correlated with a poor prognosis in patients with CRC. Furthermore, SEZ6L2 expression was inversely correlated with the expression of cytochrome C in malignant tissues in patients with CRC.

分子别名(Synonyms)

BSRP-A; PSK-1; SEZ6L2; UNQ1903/PRO4349

文献(References)

(1) An N, Zhao Y, Lan H, Zhang M, Yin Y, Yi C. SEZ6L2 knockdown impairs tumour growth by promoting caspase-dependent apoptosis in colorectal cancer. J Cell Mol Med. 2020 Apr;24(7):4223-4232. doi: 10.1111/jcmm.15082. Epub 2020 Feb 27. PMID: 32105413; PMCID: PMC7171412.

Note: HPLC results always come from liquid protein, due to absorption peak interference of trehalose in lyophilized powder.