IL1-HM213-100μg / 询价
IL1-HM213-500μg / 询价
IL1-HM213-500μgx2 / 询价
Human IL-13 Protein
Recombinant Human IL-13 Protein is expressed from HEK293 with hFc tag at the N-Terminus.It contains Gly21-Asn132 [Accession | AAK53823].
The protein has a predicted MW of 39.6 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Bis-Tris PAGE result.
>95% as determined by Bis-Tris PAGE
>95% as determined by HPLC
Less than 1 EU per μg by the LAL method.
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human IL-13 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human IL-13 is greater than 95% as determined by SEC-HPLC.
Immobilized Biotinylated Human IL-13Ra1, His Tag at 2 μg/ml (100 μl/well) on the streptavidin precoated plate (5 μg/ml). Dose response curve for Human IL-13, hFc Tag with the EC50 of 15.4 ng/ml determined by ELISA (QC Test).
Immobilized Human IL-13, hFc Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Human IL-13Ra2, His Tag with the EC50 of 7.1 ng/ml determined by ELISA.
Human IL-13, hFc Tag captured on CM5 Chip via Protein A can bind Human IL-13Ra1, His Tag with an affinity constant of 0.399 μM as determined in SPR assay (Biacore T200).
Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages (By similarity).
IL13; IL-13; interleukin 13; NC30; P600; ALRH; BHR1; MGC116786; MGC116788; MGC116789
(1) Grünig G, Corry D B , Reibman J , et al. Interleukin 13 and the evolution of asthma therapy[J]. American Journal of Clinical & Experimental Immunology, 2012, 1(1):20.
