NRG-HM1B1-100μg / 询价
NRG-HM1B1-500μg / 询价
NRG-HM1B1-500μgx2 / 询价
Human NRG1 Beta 1 Protein
Recombinant Human NRG1 Beta 1 Protein is expressed from HEK293 with His tag at the N-terminus.It contains Ser177-Glu241 [Accession | Q02297-6].
The protein has a predicted MW of 8.57 kDa. Due to glycosylation, the protein migrates to 10-13 kDa based on Bis-Tris PAGE result.
>95% as determined by Bis-Tris PAGE
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22 μm filtered solution in 50mM NaAc, 150mM NaCl (pH 5.0). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human NRG1 Beta 1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Immobilized Human NRG1 Beta 1, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Human Her3, hFc Tag with the EC50 of 35.8ng/ml determined by ELISA (QC Test).
Immobilized Human NRG1 Beta 1, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Human Her4, hFc Tag with the EC50 of 33.4ng/ml determined by ELISA.
Neuregulin-1 (NRG-1) is a ligand of the epidermal growth factor receptor (erbB), and its interaction involves activation of the glutamatergic N-methyl-Daspartate receptor, which increases the expression of the β2 subunit of the γ- aminobutyric acid receptor and subunits of the nicotinic acetylcholine receptor.
Pro-NRG1; NRG1; GGF; HGL; HRGA; NDF; SMDF; Beta1; Beta1A
Liew H, Kim YM, Choi HS, Jang AR, Churchill D, Lee SH, Suh YH. Soluble Neuregulin-1 from Microglia Enhances Amyloid Beta-induced Neuronal Death. CNS Neurol Disord Drug Targets. 2016;15(8):918-926. doi: 10.2174/1871527315666160815160505. PMID: 27577739.
