TRM-HM401B-100μg / 询价
TRM-HM401B-500μg / 询价
TRM-HM401B-500μgx2 / 询价
表达区间及表达系统(Source)
|
Recombinant Biotinylated Human TREM2 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains His19-Ser174 [Accession | Q9NZC2-1]. |
分子量大小(Molecular Weight)
|
The protein has a predicted MW of 20.3 kDa. Due to glycosylation, the protein migrates to 30-45 kDa based on Bis-Tris PAGE result. |
纯度(Purity)
|
> 95% as determined by Bis-Tris PAGE |
内毒素(Endotoxin)
|
Less than 1EU per μg by the LAL method. |
制剂(Formulation)
|
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
重构方法(Reconstitution)
|
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
存储(Storage)
|
-20 to -80°C for 12 months as supplied from date of receipt. |
Recombinant Biotinylated Human TREM2 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains His19-Ser174 [Accession | Q9NZC2-1].
The protein has a predicted MW of 20.3 kDa. Due to glycosylation, the protein migrates to 30-45 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
TREM-2 (Triggering Receptor Expressed on Myeloid cells-2) is a 35 kDa type I transmembrane member of the TREM family and Ig superfamily. Mature human TREM-2 consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. TREM-2 forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia.
PLOSL2; TREM2; TREM-2; Trem2a; Trem2b; Trem2c
(1)Ford J W , Mcvicar D W. TREM and TREM-like receptors in inflammation and disease[J]. Current Opinion in Immunology, 2009, 21(1):38-46.
TRM-HM401B-100μg / 询价
TRM-HM401B-500μg / 询价
TRM-HM401B-500μgx2 / 询价
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